[Download] "Role of Suppressor T Cells in Various Diseases (Report)" by International Journal of Biotechnology & Biochemistry # eBook PDF Kindle ePub Free
eBook details
- Title: Role of Suppressor T Cells in Various Diseases (Report)
- Author : International Journal of Biotechnology & Biochemistry
- Release Date : January 01, 2009
- Genre: Industries & Professions,Books,Business & Personal Finance,
- Pages : * pages
- Size : 80 KB
Description
Introduction Regulatory CD4+CD25+ T cells (Tregs) represent a small subset of CD4+ T cells that constitutively express the IL-2 receptor-[alpha] chain, CTL-associated antigen 4 (CTLA-4), glucocorticoid-induced TNF receptor (GITR), and class II MHC markers (Beacher-Allan et al. 2001). Unique lineage of immunoregulatory CD4+CD25+ T cells comprises ~5-10% of CD4+ T cell population. Tregs do not proliferate in response to T cell antigens but can inhibit activation of other T cells by the contact-dependent or cytokine-mediated mechanisms (Shevach 2001).A key regulatory molecule in the development and function of Treg cells is FoxP3, a transcriptional repression factor of the FOrkhead/winged box family that is expressed by all functional Treg cells except the TR1 class (Hori et al. 2003). Mutations in FoxP3 impair development of Treg cells in the thymus and are associated with inherited autoimmune diseases, such as Scurfy in the mouse and IPEX (an X-linked fatal autoimmune disorder) in humans [1, 2].FoxP3 acts as a negative regulator of cytokine production by CD4 T cells and repress transcription of IL-2 and other cytokine genes including IL-4 and IFN-[gamma] (Schubert et al. 2001). FoxP3 has been described as the master control gene for the development and function of Tregs.
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